The issue with starting Wade is it severely constricts your big man depth (you only have Love and Lopez off the bench), and it also constricts your roster flexibility since Okoro, LeVert, Cedi, Windler and Stevens are all 2/3's who can't play 4, and Wade's minutes at the 3 'waste' several of your current 2/3's..
I say this also realizing he is one of the better options with the Core 4..
Considering what the Cavs have invested in Okoro and have an upcoming team option, they have to see what they have with him first.. I see Wade as a backup option should Okoro falter..
Love, Cedi, LeVert and Neto/Rubio are your rotation with Wade, Stevens, Lopez (and later Neto) being matchup/injury dependent bench guys..