Wade and Rose bench lineup will never work.
Wade makes that lineup work because he is anchoring the offense from the post overpowering and outsmarting backup PGs. With Rose back, the backup PGs are going to defend Rose instead and Wade will no longer have the same physical advantage, and even if he does, it's not going to be nearly as effective because Rose is useless without the ball. If Rose has the ball, Wades defender is going to sag off of him and if Wade has the ball, Rose's defender is going to sag off of him and as a result we lower our penetration percentage and cutting percentage because we no longer have space to work with... things that the 2nd unit feast on.
Rose needs to be situational, anything more and it's a net negative.